It’s easy to see why Barcelona is the most-visited city in Spain. As the capital of the country’s Catalonia region, this cityscape’s cultural mosaic pieces together a 2,000-year-old hodge-podge of sun-drenched beaches, cutting edge architecture and a world-renowned dining and drinking scene. Catalan architect Antoni Gaudi left his modernist handprint all over the city, while medieval treasures linger in historic Gothic Quarter squares. Get lost in the whimsical gardens of Park Guell or savour a chef-led Catalan cooking class. Browse art collections dedicated to Picasso and Miro – or ride a cable car to the top of Montjuic Hill, relishing citywide views along the way.

France’s oldest city, Marseille blends ancient charm with Provencal beauty. In the morning, head to the fish market Quai des Belges, where trade has been going on for more than 2,600 years – stroll along the promenades and 18th-century warehouses, and grab a cafe au lait and a melon tarte from one of the cafes on the ground floor. Cruise to Provence and check out the Basilique Notre-Dame de la Garde: Built in the 19th century in a neo-Byzantine style, its golden statue of the Virgin and Child dominates the Marseille skyline. Then, take in the modern architecture and Mediterranean cultural artifacts at the MuCEM art museum, or see the craggy limestone cliffs of Calanques National Park, a half-hour drive outside the city.

Although originally called ‘Nakaia’, France’s Nice is as delightful as its name suggests to English speakers. Take a bus or taxi into Nice’s Old City to explore its history-spanning architecture and pristine French Riviera beaches with your Nice cruise. Or stick closer to Villefranche-sur-Mer, where your ship will dock, and take a day-trip to the mountaintop town of Eze. No matter how you spend your time in the de facto hub of France’s Cote d’Azur, you’ll enjoy the added benefit of being close to Italy, which means delectable pizza, fragrant espresso and the sounds of a second Romance language.

With 28 centuries of celebrated history, Rome holds the edge when it comes to unrivalled adventures. The city that sparked the world’s largest empire is very much alive today with a jumble of ancient ruins, world-renowned art and vivacious street culture. Here you can live ‘la dolce vita’, recalling the glory days of Ancient Rome and twirling forks full of pasta in a trattoria. Ride past centuries-old basilicas in a three-wheeled Ape Calessino, or stand in awe of paintings by Italian masters at Villa Borghese. Whether it’s Vatican City’s spiritual allure, Trastevere’s backstreet charms or the Colosseum’s embattled legacy – The Eternal City endures with endless adventures.

The lively cliffside village of Salerno is a gateway to the many historical and scenic coastal towns with cruises to the Amalfi Coast. Take a stroll by the water along the city’s modern promenade, or pop into a cafe for a refreshing limoncello. Break a sweat with a hike up Mount Vesuvius before you wander through the ancient city of Pompeii. Or take a drive along the coast on the winding roads, and bask in views of steep cliffs over crystal blue water.

Extravagant and vibrant, Palermo invites you into an array of flavours, colours and bustling streets. Set in a peaceful bay surrounded by Sicily’s fertile basin Conca d’Oro, named for the golden colour of the orange groves, the city bears traces of historic invasions by the Arabs, Greeks, Romans, Spanish and Normans. Head to La Vucciria market to sample almonds, marzipan, spices, peppercorns and candied fruits. Then, explore the historic centre – visit the Cathedral, which dates back to 600 AD and features Gothic, Moorish and Baroque architectural elements. Then, take the short drive to Mt Pellegrino, where you can trek up the granite cobbled hiking path and take in the refreshing greenery of the natural reserve.

The off-the-path Emilia-Romagna region of northern Italy offers adventure for every taste. Explore the ancient town of Ravenna, best known for the seemingly endless Byzantine mosaics adorning its churches and monuments. Plus a powerhouse collection of eight UNESCO sites. Or venture to nearby Bologna to wander its portico-lined streets teeming with medieval relics— not to mention some of Italy’s most delectable cuisine. In this part of Italy, you can do a bit of it all. From sunning along the beaches of Punta Marina to engine revving at the Lamborghini Museum, and catching cutting-edge modern art at the MAMbo to taking a hands-on lesson in Bolognese cooking.