Formerly a sleepy Spanish city, Barcelona has recently been reborn as an eclectic fusion of the modern and medieval. Seek inspiration from the creations of its modernist architect, Antonio Gaudí, or the Picasso Museum. Or, take in the breathtaking cathedrals in the Gothic Quarter.

This island enclave is often described as a mini-Barcelona, with a Gothic feel that has overtaken centuries of Roman and Moorish culture. Visit El Baluard, the Museum of Modern and Contemporary Art, which was built on the site of the remnants of the 16th century Bastio de Sant Pere, or shop for bargain pearls at the city’s many jewelers.

Best known as the birthplace of paella, Valencia has steadily moved onto the radar of savvy travelers. It’s a vibrant, friendly, mildly chaotic place with two outstanding fine-arts museums, an accessible old quarter, Europe’s newest cultural and scientific complex – and one of Spain’s most exciting nightlife scenes. Whole sections of the old city, for example the Carmen Quarter, have been extensively renovated. One of the best spots for exploring Valencia’s history is at the museum L’Almoina, which opened three years ago in the Carmen on the site where Valencia was founded by the Romans in 138 B.C. Here, you can walk over glass floors, looking down at a stunning assemblage of ruins excavated in the area. The exhibition includes Roman baths, tombs and a medieval Moorish ward for plague victims.

Málaga is the gateway to the Andalusian countryside and the Costa del Sol, some of the region’s most impressive beaches. It also is home to a number of magnificent palaces, including the Moorish Alcabaza and Gibralfaro.

From Cádiz you can easily get to Seville, exploring the old town with its quaint Moorish feel as well as its impressive monuments, pretty parks and lovely architecture. Along the way, restore your energy at any of the mouth-watering tapas bars offering some of the country’s finest seafood and typical Andalusian cuisine.

Tangier, a Moroccan port on the Strait of Gibraltar, has been a strategic gateway between Africa and Europe since Phoenician times. Its whitewashed hillside medina is home to the Dar el Makhzen, a palace of the sultans that’s now a museum of Moroccan artifacts. The American Legation Museum, also in the medina, documents early diplomatic relations between the U.S. and Morocco in an 1821 Moorish-style former consulate.

El Sireno, a gilded sculpture depicting a figure that is half man, half sea creature, towers over the city’s lovely gardens and well-preserved historical buildings. The legendary black salts offshore on the Islas Cies are said to bring good health. Catholic pilgrims flock to the nearby sacred cathedral of Santiago de Compostela, built over the burial spot of St. James.

Porto, Portugal’s second largest city after Lisbon, is one of Europe’s oldest cities and was registered as a World Heritage Site by UNESCO in 1996. Of course, Porto’s name itself hints at perhaps Portugal’s most famous export—port—for it is here that the fortified wine was first produced. The city is reminiscent of times gone by and you wouldn’t be far wrong to liken it to an ideal Shakespearean backdrop. Here, the skyline is composed of sky-high bell towers, opulent baroque churches and majestic beaux art buildings, which combine to create a romantic air that’s only heightened by the glorious shafts of sunlight that illuminate the city.

See why this city stands out above all others as you stroll along elaborate mosaic sidewalks and pass by the Monument to the Discoveries. A quick trolley ride transports you to the cobblestone district of Baixa. Or be lured away and pampered in the resort cities of Cascais and Estoril.