With 28 centuries of celebrated history, Rome holds the edge when it comes to unrivalled adventures. The city that sparked the world’s largest empire is very much alive today with a jumble of ancient ruins, world-renowned art and vivacious street culture. Here you can live ‘la dolce vita’, recalling the glory days of Ancient Rome and twirling forks full of pasta in a trattoria. Ride past centuries-old basilicas in a three-wheeled Ape Calessino, or stand in awe of paintings by Italian masters at Villa Borghese. Whether it’s Vatican City’s spiritual allure, Trastevere’s backstreet charms or the Colosseum’s embattled legacy – The Eternal City endures with endless adventures.

With a skyline defined by towering Mount Vesuvis, Naples is a bustling Italian city brimming with beauty. Experience its rich neoclassical architecture at sites like Gesu Nuovo Church, with its lavish interior adorned with detailed frescoes, statues and gold inlay. Go even deeper into history at the San Gennaro catacombs, where Naples’ first bishops were buried in the second century AD. Walk along the Miglio Sacro (‘Holy Mile’) and people-watch your way through the cafes and shops of the Sanita district with a zuccherato (sweetened espresso) in hand. Jump onboard a Naples cruise and take the short bus ride to the base of Mount Vesuvius – it’s an easy 20- to 30-minute hike will take you to the summit – and tour the ruins of Pompeii afterward.

Extravagant and vibrant, Palermo invites you into an array of flavours, colours and bustling streets. Set in a peaceful bay surrounded by Sicily’s fertile basin Conca d’Oro, named for the golden colour of the orange groves, the city bears traces of historic invasions by the Arabs, Greeks, Romans, Spanish and Normans. Head to La Vucciria market to sample almonds, marzipan, spices, peppercorns and candied fruits. Then, explore the historic centre – visit the Cathedral, which dates back to 600 AD and features Gothic, Moorish and Baroque architectural elements. Then, take the short drive to Mt Pellegrino, where you can trek up the granite cobbled hiking path and take in the refreshing greenery of the natural reserve.

For Renaissance treasures, nothing compares. The Uffizi is home to Michelangelo’s David, Botticelli’s Birth of Venus and Leonardo’s Annunciation – just to start. Add architectural icons like Brunelleschi’s Duomo, or the Baptistry with its Gates of Paradise.

Monte Carlo is famous for the four ‘G’s’: the Grimaldi monarchy as well as its Grand Prix, Glamour and Gambling. The famous Grand Casino is only one of several but, if you are feeling lucky, note that it operates a strict dress code and requires all players to show passports. The first thing you notice when you arrive is how pristine the mega-yachts look in the harbour. This only fuels the suspicion that their owners – rather than risk going to sea – actually prefer to tie-up permanently at one of the worlds most fashionable addresses. Monacos three main districts are all walkable from the harbour: Monaco Ville (the intriguing old town), La Condamine (business centre), and Monte Carlo (the glitzy new town). Grimaldi Prince Rainier III put Monaco on the map by marrying film star Grace Kelly in 1955 and he is now buried alongside Princess Grace in St Nicholas Cathedral in Monaco Ville.

France’s oldest city, Marseille blends ancient charm with Provencal beauty. In the morning, head to the fish market Quai des Belges, where trade has been going on for more than 2,600 years – stroll along the promenades and 18th-century warehouses, and grab a cafe au lait and a melon tarte from one of the cafes on the ground floor. Cruise to Provence and check out the Basilique Notre-Dame de la Garde: Built in the 19th century in a neo-Byzantine style, its golden statue of the Virgin and Child dominates the Marseille skyline. Then, take in the modern architecture and Mediterranean cultural artifacts at the MuCEM art museum, or see the craggy limestone cliffs of Calanques National Park, a half-hour drive outside the city.

It’s easy to see why Barcelona is the most-visited city in Spain. As the capital of the country’s Catalonia region, this cityscape’s cultural mosaic pieces together a 2,000-year-old hodge-podge of sun-drenched beaches, cutting edge architecture and a world-renowned dining and drinking scene. Catalan architect Antoni Gaudi left his modernist handprint all over the city, while medieval treasures linger in historic Gothic Quarter squares. Get lost in the whimsical gardens of Park Guell or savour a chef-led Catalan cooking class. Browse art collections dedicated to Picasso and Miro – or ride a cable car to the top of Montjuic Hill, relishing citywide views along the way.