A stop in Amsterdam offers the chance to explore the sights of one of Europe’s most colorful, dynamic and historic cities—one with a well-earned reputation as a laid-back and inviting place for people of all stripes. Visitors are naturally drawn to the historic city center where you’ll find some of the world’s top art museums, including the Rijksmuseum and the Van Gogh Museum. And at Dam Square, the Amsterdam’s largest public square, you can tour the Royal Palace before continuing to the tourist attractions on the Canal Belt. The iconic network of waterways that surrounds the downtown area offers a picturesque backdrop for sightseeing by bike or canal boat. Be sure to visit the floating Bloemenmarkt to peruse famed Dutch tulips, and take time to wander and window-shop among the narrow lanes of de Jordaan. And you won’t have to look far in Amsterdam to find delicious Dutch treats along the way. Just duck into a cozy brown café to sample a plate of bitterballen with mustard and a beer, and grab a gooey sweet stroopwafel from a street vendor as you stroll.

This Basque city combines a heady mix of ancient roots and ultramodern sensibilities. If you like modern design, Bilbao’s got striking architecture—like Frank Gehry’s shiplike Guggenheim Museum, the soaring Isozaki towers and Calatrava’s glass-bottomed Zubizuri Bridge. If you seek older cultural highlights, there are historic buildings, traditional Basque cuisine and inviting cobblestone streets to explore. Outside Bilbao’s bustling center, there’s lots to discover. Find sweeping views and surprising meals—both traditional and avant-garde—waiting to be savored in hilltop communities. Learn about the Basques’ tragic history and promising future in Guernica, the city bombed by Fascist forces and immortalized by Picasso. Or spend a day in San Sebastián, exploring the historic center, the boardwalk and the curving bay, setting some time aside to sample the city’s famous Michelin-star worthy cuisine.

Seaside cafés and a tour of a venerable working lighthouse beckon, as does Santiago de Compostela, one of Christianity’s holiest sites.

From lovely Oporto enjoy a leisurely drive along the Rio d’Ouro (River of Gold) into port wine country. Hear the fascinating story of its origin; taste test the season’s best.

Find your way in the city that launched the Age of Discovery. Cross the River Tagus on its soaring suspension bridge, watched over by a colossal statue of Christ. Wander the maze of streets in the Alfama, the old Moorish quarter, dominated by the medieval Castle of St George where peacocks strut and shriek. Stroll the Baixa and refuse to leave without a pair of elegant shoes.

Málaga is your chance to tour to the Moorish wonders of the Alhambra with its elaborate carvings, grand columns and delicate arches. Stalagmites and stalactites reach calcite fingers into the caverns of Nerja, near Malaga. 30,000 years ago, people lived in the shadowy recesses of these caves. In nearby Mijas, shop tables are laden with hand-made ceramics, and the people live in shuttered, whitewashed cottages.

Fresh sea breezes, mountain backdrops and vibrant locals have made this magical city a must-see for both international tourists and residents of Spain alike.

It’s easy to slip into the local rhythm. Spend your day exploring everything from the Old Town and Santa Bárbara Castle to the trendiest of Spanish stores. Promenade down the marble Explanada de España, an iconic and bustling boulevard dotted with palm trees. Enjoy a proper Spanish lunch that spans several courses and hours, prepared by some of the best chefs in the country. Take advantage of the proximity to the sea to dine on the freshest seafood, or try one of Alicante’s many traditional rice dishes. And don’t forget to sample the outstanding regional wines, which are also very tasty souvenirs.

Even just a day here will open your eyes to the natural beauty and subtle charms that make proud and elegant Alicante a gem of the Costa Blanca.

Famous for paella at Pepica’s, favorite of Ernest Hemingway when he came to Valencia for bullfight festivals. Overlooking the Gulf of Valencia and the Balearic Islands, this Spanish jewel blends ancient and new in its historic center, where the Barrio del Carmen neighborhood uses the old walls of the city in its more modern structures. Walk the cobblestone streets to the chic Colon Street, home to local boutiques-or take in the sublime views from Las Arenas beach or one of the many delightful plazas. Sample shore excursions: Valencia City Tour.

On the northeast coast of Spain, overlooking the Mediterranean, Barcelona is a vibrant port city, packed with centuries of iconic art and architecture—Gaudí and Picasso both called it home—and lined with sunny white-sand beaches. Explore the Catalan capital’s tourist attractions and historic neighborhoods, Modernisme and world-renowned art museums, galleries and local crafts shops—some of which are centuries old and stock traditional Catalan wares. After you see the sights, there are lively tapas bars around every corner where you can stop for a drink, a café amb llet (Catalan for espresso with steamed milk) or a snack, no matter the hour. Green spaces for picnics, long walks and respite from the hustle and bustle are scattered throughout Barcelona’s attractions: There’s Gaudí’s mosaic-decorated park, a neoclassical maze at the Laberint d’Horta, as well as plenty of high places (mountains, monuments and edifices) where sightseeing visitors can take in the view. A short trip from Barcelona by car or train, luxury outlets, cava wineries, a mountaintop abbey and the sandy beaches of the Mediterranean coast await.