Dover, in the county of Kent in southeast England, has understandably been one of the most important ports of entry to the country for centuries, given its location on the English Channel across from France. The famous White Cliffs of Dover greet you as you arrive, and the city has a number of historic sights, including a medieval castle. For many travelers, however, it is primarily a gateway to London. Few places can compete with England’s capital for sheer energy, atmosphere and variety. London’s vibrancy—in art, in music, in architecture—is formidable. It’s a city with not only multiple attractions, grand structures and great cultural institutions (though there are plenty of those) but also scenic parks, walkable villages and striking modern additions.Culinary pioneers are reviving traditional techniques and introducing menus that are at the forefront of the world’s premier restaurant experiences. Leg-powered sightseeing (by bike or on foot) around London maximizes opportunities for stumbling across secret alleys, courtyards housing quirky art galleries and tiny old pubs serving fresh British ales. Shoppers will want to check out the items at some of the retail emporiums known the world over as well as diminutive boutiques stocking unique souvenirs.

A stop in Amsterdam offers the chance to explore the sights of one of Europe’s most colorful, dynamic and historic cities—one with a well-earned reputation as a laid-back and inviting place for people of all stripes. Visitors are naturally drawn to the historic city center where you’ll find some of the world’s top art museums, including the Rijksmuseum and the Van Gogh Museum. And at Dam Square, the Amsterdam’s largest public square, you can tour the Royal Palace before continuing to the tourist attractions on the Canal Belt. The iconic network of waterways that surrounds the downtown area offers a picturesque backdrop for sightseeing by bike or canal boat. Be sure to visit the floating Bloemenmarkt to peruse famed Dutch tulips, and take time to wander and window-shop among the narrow lanes of de Jordaan. And you won’t have to look far in Amsterdam to find delicious Dutch treats along the way. Just duck into a cozy brown café to sample a plate of bitterballen with mustard and a beer, and grab a gooey sweet stroopwafel from a street vendor as you stroll.

This Basque city combines a heady mix of ancient roots and ultramodern sensibilities. If you like modern design, Bilbao’s got striking architecture—like Frank Gehry’s shiplike Guggenheim Museum, the soaring Isozaki towers and Calatrava’s glass-bottomed Zubizuri Bridge. If you seek older cultural highlights, there are historic buildings, traditional Basque cuisine and inviting cobblestone streets to explore. Outside Bilbao’s bustling center, there’s lots to discover. Find sweeping views and surprising meals—both traditional and avant-garde—waiting to be savored in hilltop communities. Learn about the Basques’ tragic history and promising future in Guernica, the city bombed by Fascist forces and immortalized by Picasso. Or spend a day in San Sebastián, exploring the historic center, the boardwalk and the curving bay, setting some time aside to sample the city’s famous Michelin-star worthy cuisine.

Seaside cafés and a tour of a venerable working lighthouse beckon, as does Santiago de Compostela, one of Christianity’s holiest sites.

From lovely Oporto enjoy a leisurely drive along the Rio d’Ouro (River of Gold) into port wine country. Hear the fascinating story of its origin; taste test the season’s best.

Find your way in the city that launched the Age of Discovery. Cross the River Tagus on its soaring suspension bridge, watched over by a colossal statue of Christ. Wander the maze of streets in the Alfama, the old Moorish quarter, dominated by the medieval Castle of St George where peacocks strut and shriek. Stroll the Baixa and refuse to leave without a pair of elegant shoes.

Málaga is your chance to tour to the Moorish wonders of the Alhambra with its elaborate carvings, grand columns and delicate arches. Stalagmites and stalactites reach calcite fingers into the caverns of Nerja, near Malaga. 30,000 years ago, people lived in the shadowy recesses of these caves. In nearby Mijas, shop tables are laden with hand-made ceramics, and the people live in shuttered, whitewashed cottages.

Fresh sea breezes, mountain backdrops and vibrant locals have made this magical city a must-see for both international tourists and residents of Spain alike.

It’s easy to slip into the local rhythm. Spend your day exploring everything from the Old Town and Santa Bárbara Castle to the trendiest of Spanish stores. Promenade down the marble Explanada de España, an iconic and bustling boulevard dotted with palm trees. Enjoy a proper Spanish lunch that spans several courses and hours, prepared by some of the best chefs in the country. Take advantage of the proximity to the sea to dine on the freshest seafood, or try one of Alicante’s many traditional rice dishes. And don’t forget to sample the outstanding regional wines, which are also very tasty souvenirs.

Even just a day here will open your eyes to the natural beauty and subtle charms that make proud and elegant Alicante a gem of the Costa Blanca.

Famous for paella at Pepica’s, favorite of Ernest Hemingway when he came to Valencia for bullfight festivals. Overlooking the Gulf of Valencia and the Balearic Islands, this Spanish jewel blends ancient and new in its historic center, where the Barrio del Carmen neighborhood uses the old walls of the city in its more modern structures. Walk the cobblestone streets to the chic Colon Street, home to local boutiques-or take in the sublime views from Las Arenas beach or one of the many delightful plazas. Sample shore excursions: Valencia City Tour.

On the northeast coast of Spain, overlooking the Mediterranean, Barcelona is a vibrant port city, packed with centuries of iconic art and architecture—Gaudí and Picasso both called it home—and lined with sunny white-sand beaches. Explore the Catalan capital’s tourist attractions and historic neighborhoods, Modernisme and world-renowned art museums, galleries and local crafts shops—some of which are centuries old and stock traditional Catalan wares. After you see the sights, there are lively tapas bars around every corner where you can stop for a drink, a café amb llet (Catalan for espresso with steamed milk) or a snack, no matter the hour. Green spaces for picnics, long walks and respite from the hustle and bustle are scattered throughout Barcelona’s attractions: There’s Gaudí’s mosaic-decorated park, a neoclassical maze at the Laberint d’Horta, as well as plenty of high places (mountains, monuments and edifices) where sightseeing visitors can take in the view. A short trip from Barcelona by car or train, luxury outlets, cava wineries, a mountaintop abbey and the sandy beaches of the Mediterranean coast await.

Thick sandstone walls fortify Valletta, holding within its stone streets and glorious architecture. It fees like a travesty, walking over the detailed inlaid marble floors of the the cathedrals, but they are there to be seen and appreciated. The Silent City is Mdina, on the far side of the island, where no cars are permitted to disrupt the serene streets. Keep an eye out for the legendary, aged yellow buses of Malta which appear to be on their last legs, but are in fact a revered and flawlessly maintained piece of Maltese heritage.

Haggle for handcrafted jewelry in Khan el-Khalili, Cairo’s giant souk. Hear the call to prayer. Venture out to Giza, where the iconic pyramids and sphynx testify to the glory that was ancient Egypt.

Haggle for handcrafted jewelry in Khan el-Khalili, Cairo’s giant souk. Hear the call to prayer. Venture out to Giza, where the iconic pyramids and sphynx testify to the glory that was ancient Egypt.

On the island’s south coast, Limassol is very much in the Greek sector of Cyprus. Nearby crusaders’ castles, Greco-Roman ruins, olive groves and vineyards all speak to a lifestyle that is intrinsically Hellenic, and wizened lacemakers weave the traditions of their ancestors into their detailed work.

Rhodes, set behind impregnable 14th-century walls, invites you to navigate through crooked streets to shop for sea sponges and visit the gorgeous Palace of the Grand Masters from where the Knights of St John set out on the Crusades. Tour to the village of Lindos and climb to the Acropolis. Look down and you’ll see where St Paul landed, as well as the rocky peninsulas where many believe the Colossus of Rhodes once stood. This 110-foot-tall statue of Helios was destroyed by an earthquake, and its remains were melted down by the Arabs for scrap metal.

Kusadasi in Turkey is the gateway to one of the most legendary cities of the ancient world: Ephesus. St. Paul preached in its Great Theater, while the facade of the Celsus Library survives as a testament to the city’s role as a center of learning and culture.

Not far from Ephesus, the Temple of Artemis (also known as the Temple of Diana), one of the Seven Wonders of the ancient world, once stood, drawing pilgrims from around the Mediterranean. While it no longer stands, it is possible to walk amongst its foundations and the remains of its towering columns.

Other historic sites can also be found nearby: The House of Mary is believed to be the home of Jesus’s mother at the end of her life, and the Basilica of St. John, constructed in the 6th century, marks the location of his tomb. (Like Mary, he spent his final years in Ephesus.) Nearby, the Selcuk fortress reflects the period of Byzantine and Ottoman control of the region.

From ancient wonders to holy sites, there are few ports in the Mediterranean as magical as Kusadasi, and a day here is a day spent in the company of some of antiquity’s greatest figures.

Blurring the line between east and west, Istanbul stands at the crossroads of two continents. The city’s architecture is rivalled only by its spectacular natural setting on the Bosphorus Strait. See the Blue Mosque, the Topkapi Palace and the Byzantine Church of St Sophia. Take time to wander through the Grand Bazaar or the Spice Market and sample baklava and shish kebabs.

Blurring the line between east and west, Istanbul stands at the crossroads of two continents. The city’s architecture is rivalled only by its spectacular natural setting on the Bosphorus Strait. See the Blue Mosque, the Topkapi Palace and the Byzantine Church of St Sophia. Take time to wander through the Grand Bazaar or the Spice Market and sample baklava and shish kebabs.

No modern metropolis is more steeped in myth than Athens, Greece. From the gritty port of Piraeus—gateway to Greece’s fabled isles—to the Parthenon—eternal symbol of Western civilization—Athens has attracted adventurers and classicists for centuries. This heritage is still very much alive for modern visitors sightseeing in Athens: ancient stadiums and temples dwell alongside apartment blocks, modern performances are staged in the marble amphitheaters where Greek drama was born and millennia-old monuments are scattered in the archaeological park that circles the Acropolis.

One of the world’s oldest maritime powers, Athens is blessed with a balmy climate and stunning coastline. The seaside suburbs of Athens are scalloped with sandy beaches, fancy yacht clubs and glamorous beach bars. While the Athenian lifestyle is known for late-night dinners and dancing until dawn, the city shines brightly by day in the bustling markets, lively cafés and fascinating museums that illuminate Greece’s past and present. Contemplate the magnitude of all that culture and ancient tourist attractions while marveling at the sun setting into the Aegean or rising over the Acropolis.